Pfizer Lecture Theatre, Department of Chemistry, Lensfield Road, Cambridge.Therefore the functional groups in the amino acids help in the. Materials Chemistry Research Interest Group The peptide linkage means the linked structures of protein which makes the condition more stable.Tell a friend about this talk: This talk is included in these lists: In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as. This talk is part of the Materials Chemistry Research Interest Group series. In addition, the peptides can be used in the preparation of other architectures, such as molecular capsules, spherical clusters and so on. Therefore the tubes can be designed for organic, aqueous or lipidic media allowing their implementation in a variety of applications.
Peptides building blocks series#
(A) A series of chiral non-natural amino acids are inserted at i, i + 4 or i, i + 7 positions and the terminal olefins cross-linked by RCM, yielding cross-links that span one or two helical turns, respectively. These peptides allowed the construction of tubular structures of nanometric dimensions with tunable internal and external properties. Building blocks of all-hydrocarbon peptide stapling. The versatility of peptides as a building block is evident through the introduction of reactive units that allow for more robust, stiffer covalently (or chemically) crosslinked hydrogel networks, a necessity for 3D printing of mechanically stabilized materials, to be prepared. In the last few years our research group has been mainly working with disc-shaped cyclic peptides that contain cyclic gamma-amino acids. Cyclic components have restricted conformational freedom adopting kinetically stable structures that can be implemented in supramolecular applications.
In this respect, peptides are powerful tools for the preparation of novel nanobiomaterials because of their unique folding and self-assembly properties. The ability to construct complex functional materials using a small number of components represents an efficient synthetic strategy for the rapid generation of novel architectures and functions. If you have a question about this talk, please contact Sharon Connor. In the present work, we have used site 1 and site 2 peptides as building blocks to make synthetic and recombinant homodimers and heterodimers to create molecules that activate the IR with high potency and specificity.
Peptides building blocks download#
Cyclic Peptides: Building Blocks for Supramolecular DesignsĪdd to your list(s) Download to your calendar using vCal
0 kommentar(er)
